PPARGC1A and infection: The same picture was present in the maximal cellrespiration rate: this index increased only after PGC-1α-a infection.Conversely, NT-PGC-1α-a induced a more pronounced increase inVEGFA gene expression and activation of angiogenesis.Transgenic mice overexpressing the truncated isoform NT-PGC-1α-b(PGC-1α4 in Thom et al.) were used to confirm thephysiological significance of these findings in vivo.