OPTN and amyotrophic lateral sclerosis: The most common geneticcauses of ALS include expansion of the GGGGCC hexanucleotide repeats in thefirst intron/promoter of the C9ORF72 gene [28-30],as well as mutations in the genes SOD1 (superoxidedismutase 1, encodes Cu/Zn-binding superoxide dismutase 1) [31], TDP-43 (TARDNA-binding protein 43) [32],FUS (fused in sarcoma, RNA-binding proteinFUS) [33, 34], ANG (angiogenin,ribonuclease) [35], OPTN(optineurin) [36], and VCP (valosin containingprotein) [37].