PIK3R1 and type 2 diabetes mellitus: In this respect, three major target genes [c-Cbl protein, phosphoinositide-3-kinase regulatory subunit 1 (PI3KR1), and the suppressor of cytokine signaling 1 (SOCS1)] for the in silico intersection between two of the more relevant miRNAs in the context of inflammation affecting fat cells, the miR-155 and miR-221 (Additional file 1: Table S3), are involved in insulin pathway (Additional file 3: Figure S2) and, thus, may participate of insulin resistance and type 2 diabetes (Additional file 3: Figure S3) [31].