Non-specific adsorption of PEI/DNA complexes encoding for VEGF for the subsequent substrate-mediated delivery of the vectors resulted in the robust expression of VEGF in H9C2 myoblast cells and triggered local angiogenesis adjacent to the electrospun fibers, demonstrating the future potential of this method for the treatment of myocardial infarction [87]. This evidence concerns the gene VEGFA and myocardial infarction.