Some of them are considered highly specific for SSc, including anti-topoisomerase 1 (ATA), anti-centromere (CENP), and anti-RNA polymerase III, and these were recently added to the 2013 American College of Rheumatology/European League against Rheumatism (ACR/EULAR) SSc classification criteria (4). This evidence concerns the gene ATM and systemic sclerosis.