TRIM21 and systemic sclerosis: In an Italian cohort of 210 SSc patients in which a commercially available LIA for the simultaneous detection of 13 SSc-associated autoantibodies was used, with the exception of anti-Ro52/TRIM21 (specificity of 50%), all the autoantibodies were very specific (from 93.3% of anti-PMScl-75 to 100% of anti-PDGFR, AFA, and anti-RP-11) for SSc (5).