An increase in plasma IL-6, IL-8, and MCP-1 levels observed in obesity can also be the result of a cytokine-dependent induction of NFκB, a transcription factor with a central role in the induction of a chronic inflammatory state associated with obesity, development of type 2 diabetes, cardiovascular risk, and insulin resistance (Gonzales and Orlando, 2008). The gene discussed is NFKB1; the disease is obesity due to melanocortin 4 receptor deficiency.