Further, overproduction of IL-6 and MCP-1 by inflamed adipocytes could be directly linked with development of type 2 diabetes in obese patients where the paracrine action of MCP-1 decreases PPARγ expression thus leading to enhanced insulin resistance of adipocytes (Serrano-Marco et al., 2012). The gene discussed is CCL2; the disease is type 2 diabetes mellitus.