SIRT1 and obesity due to melanocortin 4 receptor deficiency: This places NFκB in a central position to be the mediator of obesity-associated inflammatory effects and links a number of in vivo and in vitro studies showing an inhibitory role of the resveratrol targets Sirt1, and AMPK on NFκB (Pfluger et al., 2008; Yoshizaki et al., 2009; Zhu et al., 2011; Lin et al., 2012; references in Salminen et al., 2011).