Although all these data indicate that resveratrol can alleviate obesity-induced upregulation of IL-6, IL-8, and MCP-1 in adipose tissue, it has not been fully elucidated by which molecular mechanisms resveratrol exerts its effect on IL-6, IL-8, and MCP-1 under inflammatory conditions. This evidence concerns the gene CCL2 and obesity due to melanocortin 4 receptor deficiency.