Overexpression of APP, particularly the soluble N-terminal ectodomain (sAPP), has been linked to carcinogenesis, including cancers originating from the nasopharynx, oral cavity, lung, breast, thyroid, parathyroid, colon, testicles, and pancreas (Takagi et al., 2013; Yamada et al., 2013). Here, APP is linked to cancer.