The improved therapeutic potential of Ad.CTV-m7 is mediated by the mda-7/IL-24 transgene, which when translated produces and secretes MDA-7/IL-24 protein that induces “bystander” [15, 16] cancer-specific cytotoxic effects eliminating both primary transduced tumor cells as well as adjacent non-transduced tumor cells and distant metastases [11, 12, 15, 17]. The gene discussed is IL24; the disease is neoplasm.