IL24 and cancer: This was accomplished by using a ubiquitous cancer-selective minimal promoter derived from rodent progression elevated gene-3 (PEG-3) [35] to control E1A expression, with concomitant production of the IL-10 gene family member mda-7/IL-24 that induces cancer-selective apoptosis and toxic autophagy [45, 55], referred to as a Cancer Terminator Virus (CTV; Ad.PEG-E1A-mda-7; Ad.PEG-CTV-m7) [10-14, 22].