IL24 and neoplasm: Moreover, we observed that both Ad.tCCN1-CTV-m7 and Ad.tCCN1-E1A (CRCA) reduced the size of the primary tumor (injected tumor), but the reduction of the secondary tumor was more prominent with Ad.tCCN1-CTV-m7 and Ad.PEG-CTV-m7 as compared to Ad.tCCN1-E1A (CRCA lacking mda-7/IL-24) infected mice, supporting the superiority of a CRCA with an additional therapeutic arm, such as mda-7/IL-24, e.g., Ad.tCCN1-CTV-m7 and Ad.PEG-CTV-m7 (our previously generated CTV), in diminishing tumor growth at distant sites.