A targeted analysis of c.638G>A [p.Arg213Gln] and c.869G>A [p.Arg290His], mutations initially found in a TP53 mutation screen of HBC families, did not identify any additional carriers among the 381 French Canadian women with breast cancer before age 50 years that were not selected for a family history of cancer [10]. This evidence concerns the gene TP53 and breast cancer.