It has been reported that Ddx5 regulates the splicing of tau gene [31], a protein critical for cytoskeleton maintenance and axonal transport and a key player in AD: this suggests that the early anomaly in the Parvulin complex, may trigger the tauopathy observed that appears in the AD11 model from 2–4 months onwards [18,19]. The gene discussed is DDX5; the disease is tauopathy.