CCND1 and pancreatic adenocarcinoma: During G1, cyclin D1 accumulates in the nucleus, but is exported to the cytoplasmic space when the cell enters S-phase [48], possibly implying a more intense cytoplasmic cyclin D1 staining in high proliferating aggressive tumors, a correlation found in pancreatic adenocarcinoma [51], and suggestively explaining the positive correlation with Ki67.