In present study, the aim is to investigate the prognostic and predictive roles of JWA/XRCC1 mRNA expressions and to explore the synergistic effect of JWA/XRCC1/BRCA1mRNA expression on molecular staging in personalized therapy of advanced ESCC who received cisplatin- or docetaxel-based treatments. This evidence concerns the gene XRCC1 and esophageal squamous cell carcinoma.