However, the prognostic and predictive roles of JWA/ XRCC1/BRCA1 mRNA expression were firstly proved in personalized therapy for patients with advanced ESCC treated with cisplain- or docetaxel-based regimens and indicated the need to further validate in prospective adequately designed clinical trials. The gene discussed is XRCC1; the disease is esophageal squamous cell carcinoma.