Cox proportional hazard analysis revealed that high JWA (HR 0.22; 95% CI 0.13-0.37; P < 0.001) or high XRCC1 mRNA expression (HR 0.36; 95% CI 0.21-0.63; P < 0.001) emerged as independent prognostic factors associated with increased OS, whereas low tumor differentiation grade (HR 1.45; 95% CI 1.06-1.97; P = 0.019) emerged as higher risk for mortality associated with decreased mOS (Table 4). This evidence concerns the gene XRCC1 and neoplasm.