For example, the AUC at year 3 was 0.765 for the combination of clinical risk score with JWA plus XRCC1 and 0.769 for the combination of clinical risk score with JWA, which showed that JWA plus XRCC1 mRNA expression were not better than JWA alone as a predictor for survival of patients with ESCC in present study. The gene discussed is XRCC1; the disease is esophageal squamous cell carcinoma.