Bcl2-associated athanogene 3 (BAG3) is a 575 amino acid anti-apoptotic protein that is constitutively expressed in the heart, skeletal muscle and some cancers and serves as a co-chaperone of both the constitutively and non-constitutively expressed heat-shock proteins (Hsc/Hsp) [1, 2] (Fig. 1). The gene discussed is BAG3; the disease is cancer.