BAG3 and cancer: In addition, BAG3 expression is increased in a large number of cancers including: acute lymphocytic and B cell chronic lymphocytic leukemia [52, 53] thyroid carcinoma [54]; melanomas [55] non-small-cell lung cancer [56]; hepatocellular carcinoma [57]; pancreatic adenocarcinoma [58], small cell carcinoma of the lung [59] and glioblastoma [60].