As a focal adhesion complex protein that regulates integrin interactions with the ECM, Talin-1 has been identified as a novel regulator of the invasive and metastatic potential of tumor cells, as overexpression of Talin-1 significantly enhanced the migration and invasion of prostate cancer and OSCC cells in vitro, and was associated with advanced tumour stage and poorer clinical outcome [17,18]. This evidence concerns the gene TLN1 and Familial prostate cancer.