Further investigation revealed two types of Angptl4 protein in NS: (a) a hyposialylated form secreted from podocytes in MCD [80, 81]; (b) a neutral pI sialylated form of Angptl4 is increased in the circulation of patients with MCD, MN, FSGS, and CG [82]. This evidence concerns the gene ANGPTL4 and focal segmental glomerulosclerosis.