CD44 and viral infectious disease: These cyclical base preferences, which were absent from in vitro datasets (Figure 4C, E), and reminiscent of the A/T-rich periodicity exhibited by nucleosome-bound DNA (Figure 4A), indicated that PFV and HIV-1 IN select for their preferred local tDNA sequences in the context of nucleosomal DNA during virus infection [41,42] (Figure 4).