The calcium signaling pathway, wnt signaling pathway, focal adhesion, phosphatidylinositol signaling system, regulation of actin cytoskeleton, mitogen-activated protein kinase (MAPK) signaling pathway, TGF-beta signaling pathway, gap junction, and hedgehog signaling pathway are often deregulated through aberrant methylation in NPC (adjusted P < 0.2) (Table S4). Here, WNK2 is linked to nasopharyngeal carcinoma.