In contrast to subjects in quartile 1 (8.42-8.69 mg/dl), there were significantly increased risk of LVH with subjects in quartile 2 [(8.70-8.93 mg/dl), OR (95% CI) = 1.836 (1.152-2.924), p = 0.011] and quartile 4 [(9.23-10.42 mg/dl), OR (95% CI) = 2.909 (1.792-4.720), p < 0.001], after adjusted for possible confounding factors including Alb/Cr, creatinine, albumin and SBP in model 1, further adjusted for age, gender and smoking and the use of ACEI or ARB medication in model 2, and furthermore adjusted for dyslipidemia, HbA1c, obesity and HOMA-IR in model 3. The gene discussed is ALB; the disease is obesity due to melanocortin 4 receptor deficiency.