We found no association between MAPKBP1 expression and other gene mutations, but MAPKBP1high patients with CN-AML were more likely to have a high expression of ERG1, WT1, DNMT3B and TCF4 (P < 0.001, P < 0.001, P < 0.001, and P < 0.001, respectively). This evidence concerns the gene TCF4 and acute myeloid leukemia.