HOXB8 and acute myeloid leukemia: The up-regulated genes included some of those previously found to be involved in AML, including CDK6 and CCND2 that encode a cyclin kinase, MYCN, MYB, WT1, members of the HOX gene family (HOXB2, HOXB3, HOXB8, HOXA3, HOXA4, and HOXA5) that encode transcription factor proteins, and c-kit that encodes a tyrosine kinase.