We observed a decrease in the frequency and absolute numbers of DCs, defined as CD11c+MHCII+ cells, in B16F10 melanoma-bearing mice compared with non-tumour-bearing mice (2.6-fold; Fig. 1a), with both CD8+ and CD8− DCs being affected but preserved at equal ratios (Supplementary Fig. 1A). The gene discussed is CD8A; the disease is melanoma.