On the other hand, it is worth mentioning that miR-7a/b and mithramycin effectively suppressed the expression of Sp1 and collagen I in CFs, which may explain our unpublished observation that miR-7a/b strongly reduced the expression of Sp1 and collagen I in the border zones of hearts in a mouse model of myocardial infarction, suggesting that ANG II may be persistently overexpressed. The gene discussed is SP1; the disease is myocardial infarction.