Within the top network, nFGFR1 targeted promoters of diverse genes including tumor protein 53 (Tp53), checkpoint kinase 1/2, Dkk1 and Camk2d (Fig 4B and S4A Fig), all of which are known to control the cell cycle and are deregulated in various types of cancer [39–41]. The gene discussed is CAMK2D; the disease is cancer.