As for the discordant correlations between anal HPV infection and CD4 count or ART in different researches [16–19], our findings showed that HIV-positive MSM with a CD4+ T cell level higher than 394 cells/μL may be more susceptive to infection by LR-HPV than those with less than that and ART might be a protective factor for HR-HPV infection. This evidence concerns the gene CD4 and infection.