It was previously demonstrated that MSCs infusion in only STZ or STZ+HFD diabetes animal models is accompanied by decrease of hyperglycemia as observed in the present study, however in most of the studies, the experimental period was shorter than the one in the present study, even though in most of the studies, the experimental period was shorter than in the present study [13,14,15,16,17,20,22,38] and there was increase of plasma insulin levels[14,15,20,22,38]. Here, INS is linked to diabetes mellitus.