In the light of the close relationship between CYLD and apoptosis (reviewed in [41]), it could be speculated that the deregulation of the Optn/TBK1/CYLD axis could be involved in the neuronal cell death observed in Open Angle Glaucoma and familial ALS, independently of its effect on the antiviral immune pathway. The gene discussed is TBK1; the disease is open-angle glaucoma.