Several phosphatases have been identified as regulators of TBK1 phosphorylation, including the inositol 5’ phosphatase SHIP-1 or protein phosphatase Mg2+/Mn2+ dependent 1B (PPM1B/PP2Cβ), during TLR3 stimulation or virus infection, respectively [19,20]. This evidence concerns the gene PPM1B and viral infectious disease.