PBRM1 and cancer: This analysis shows that the 1CT7 specific mutated genes are altered in 30.4% of all CRC cases whereas A1309 specific mutated genes are altered in 73.6% of all CRC cases, among which five genes are known cancer genes, i.e. PBRM1, MYB, PRDM16, BCR and NUP214 (Figure 1).