The 3 antibodies identified similarly a significant increase in ICC area in Spry4 KO colon (p value <0.05 for each antibody) and in KitWT/K641E colon (KIT rabbit p value <0.001, KIT goat and PDE3A p value < 0.01) compared to WT. The gene discussed is PDE3A; the disease is intrahepatic cholangiocarcinoma.