SPRY4 and intrahepatic cholangiocarcinoma: Although ICC hyperplasia appeared more pronounced in KitWT/K641E than in Spry4 KO, differences between KitWT/K641E and Spry4 KO were not significant (p value PDE3A = 0.2509, p value KIT rabbit = 0.2668, p value KIT goat = 0.3572).