SPRY4 and intrahepatic cholangiocarcinoma: Noteworthy, Spry4 expression, detected by in situ hybridization, has been reported in mouse embryo, in stomach at embryonic day 11.5 (E11.5) and in intestine at E12.5 and E14.5 [47], i.e. around the time where ICC differentiation starts [48–50].