PDE3A and intrahepatic cholangiocarcinoma: Was detected in the hyperplastic PDE3A-ir ICC layer of P10 KitK641E/K641E animals (S9 Fig) but, in all other genotypes, at both P10 and 3 month old, pp70S6-ir was detected only in the myenteric plexus of the antrum but not in PDE3A-ir ICC (Fig 6).