Pde3a also appeared among the genes upregulated in KitK641E/K641E antrum, presenting massive hyperplasia of KIT-ir ICC, compared to WT littermate and PDE3A-ir localized in KIT-ir ICC in the antrum of WT and KitK641E (homozygous and heterozygous) mice. This evidence concerns the gene PDE3A and intrahepatic cholangiocarcinoma.