In conclusion, the results of this exploratory pilot study showed SNPs (rs2427827 and rs2251746) in the FcεR1α promoter region are associated with the phenotype of IgE-mediated allergic diseases, such as total IgE, Der p2-specific IgE, IgE producing B cells, Der p2-induced FcεR1α mRNA expression and Cε expression. The gene discussed is IGHE; the disease is allergic disease.