A deletion of amino acid arginine 14 in the coding region of the PLN gene (R14del) was first discovered in a large Greek family with hereditary DCM5 and DCM patients heterozygous for the R14del mutation exhibit left ventricular dilation, contractile dysfunction and episodic ventricular arrhythmias, with overt heart failure by middle age in some cases5, 8, 9. This evidence concerns the gene PLN and familial dilated cardiomyopathy.