Although the molecular mechanism underlying the pathogenesis of R14del-induced DCM remains unclear, experimental evidence in a mouse model has suggested a link between PLN R14del mutation and the impairment of cardiac Ca2+ cycling, an effect that may be related to destabilization of the pentameric structure of PLN and SERCA2a super inhibition5. The gene discussed is PLN; the disease is familial dilated cardiomyopathy.