SIRT7 and neoplasm: Ourobservations that high SIRT7 expression is associated with aggressive metastaticphenotypes of human tumors, and that SIRT7 depletion significantly impairs bothprimary tumor growth and metastatic spread in mouse tumor models, suggestthat pharmacologic targeting of SIRT7 might be a promising therapeuticstrategy, and could be used in the context of combinatorial therapy with other HDACinhibitors.