Moreover, examination of prostate cancer patient microarrayexpression datasets14 revealed that while SIRT7 expression ismodestly increased (p = 0.039) in prostate cancer compared to normal prostatetissue controls (Fig. 1D), SIRT7 levels are much moredramatically elevated (p = 4.5e-5) in metastatic lymph node samples compared toprimary prostate tumors (Fig. 1E). This evidence concerns the gene SIRT7 and prostate cancer.