CDH1 and cancer: During this reversible process, expression of key epithelialmaintenance factors such as E-cadherin (CDH1) is suppressed, leading to loss ofE-cadherin-mediated cell–cell adhesion and other epithelial traits.Concomitantly, expression of mesenchymal markers and extracellular matrix remodelingenzymes is increased, together with a profound reorganization of the actin cytoskeleton.This phenotypic EMT reprogramming endows cancer cells with the plasticity and motilitynecessary to undergo the invasion-metastasis cascade.