IDUA and Hurler-Scheie syndrome: Mucopolysaccharidosis type I (MPS I) is caused by a deficient activity of alpha-L-iduronidase (IDUA; EC 3.2.1.76) and is divided into three subtypes based on the severity of symptoms: Hurler syndrome (severe, OMIM 607016), Hurler–Scheie syndrome (intermediate, OMIM 607015), and Scheie syndrome (attenuated, OMIM 607016) [1–3].