Given the critical roles of the AKT-GSK3β-cyclin D1 and AKT-p27Kip1 signaling pathways in cell cycle transition, our results suggest that miRNA-302a might induce G1/S cell cycle arrest in PCa cells by simultaneously inhibiting the AKT-GSK3β-cyclin D1 and the AKT-p27Kip1 pathway, thereby suppressing PCa cell proliferation. This evidence concerns the gene AKT1 and posterior cortical atrophy.