INS and obesity due to melanocortin 4 receptor deficiency: Nevertheless, new factors have been discovered that induce adipogenesis, such as thyroid hormone responsive Spot 14 (THRSP or S14), another specific factor whose gene expression and protein levels in lipogenic tissues are strongly linked to glucose thyroid hormone, insulin, and glucose and that is directly associated with adipogenesis in human adipocytes but inversely related to obesity and omental fat accumulation [78].