RETN and Insulin resistance: In the present study, we aimed to (1) identify whether the development of NAFLD induced by HFD feeding in mice is associated with overexpression of resistin mRNA and protein in adipose tissue and the liver; (2) observe whether inhibition of resistin expression with synthetic RNA oligo attenuates metabolic and histological abnormalities in NAFLD; and (3) clarify whether and which inflammatory cytokines and signalling molecules are involved in resistin-mediated hepatic insulin resistance and NAFLD.