Also, AGE-modified beta2M (AGE-beta2M) related to hyperglycemia may accelerate the inflammatory procedure and may directly participate in the pathobiology of amyloid formation in vessels wall by stimulating chemotaxis of monocytes and synthesis of cytokines from macrophages (interleukin-1β, TNF-α, and interleukin-6) [17,18]. Here, TNF is linked to Hyperglycemia.