Pathophysiologically, lymph node amyloidosis has been associated with an underlying clonal lymphoproliferative disorder such as lymphoplasmacytic lymphoma, marginal zone lymphoma, and chronic lymphocytic leukemia [3, 11, 15, 16] and may be associated with an IgM monoclonal paraproteinemia [12–14]. This evidence concerns the gene CD40LG and B-cell chronic lymphocytic leukemia.