Interestingly, neutrophils isolated from CTx patients yielded an 88% decrease in their capacity to release IL-8 under LPS stimulation (powerful proinflammatory mediator), whereas this reduction was less significant in response to weaker proinflammatory mediators (fMLP and TNF-α (Figure 2). This evidence concerns the gene CXCL8 and cerebrotendinous xanthomatosis.