SHH and neoplasm: As can be seen, mechanisms of anti-tumor properties of MSCs are not fully elucidated and more insights are awaited, it is presumed that it has a strong relation to downregulation of Akt, NFkB & Wnt signaling pathways.75 Stem cells and tumor cells have similar signaling pathways regulating self-renewal and differentiation, including Wnt, Notch, Shh and BMP pathways.76,77,78 Stem cells possess strong regulatory control over these pathways, while tumor cells do not possess the same.