As can be seen, mechanisms of anti-tumor properties of MSCs are not fully elucidated and more insights are awaited, it is presumed that it has a strong relation to downregulation of Akt, NFkB & Wnt signaling pathways.75 Stem cells and tumor cells have similar signaling pathways regulating self-renewal and differentiation, including Wnt, Notch, Shh and BMP pathways.76,77,78 Stem cells possess strong regulatory control over these pathways, while tumor cells do not possess the same. This evidence concerns the gene AKT1 and neoplasm.