Several studies showed a association between pro- and anti-inflammatory cytokines dysregulation with depression symptoms.43,44 Similar to our study, in Dhabhar et al. study showed that depressed subjects expressed significantly higher IL-6/IL-10 ratios.39 Also, Taraz et al. have shown a significant increase in the IL-6/IL-10 ratio in depressed hemodyalysis patients.45 The gene discussed is IL10; the disease is major depressive disorder.