Considering to importance of cytokines in psychological distress, we investigated the association of depression with pro-inflammatory markers of IL-6, and hs-CRP and anti-inflammatory cytokine (IL-10) in patients undergoing either autologous or allogeneic transplant at Taleghani BMT transplantation center affiliated to Shahid Beheshti University of Medical Sciences, in Tehran, Iran. The gene discussed is IL10; the disease is depressive disorder.