Considering to importance of cytokines in psychological distress, we investigated the association of depression with pro-inflammatory markers of IL-6, and hs-CRP and anti-inflammatory cytokine (IL-10) in patients undergoing either autologous or allogeneic transplant at Taleghani BMT transplantation center affiliated to Shahid Beheshti University of Medical Sciences, in Tehran, Iran. This evidence concerns the gene IL6 and depressive disorder.