JARID2 and microcephaly: Patient P2, a 48-month-old female with ID, DD, and facial dysmorphisms (Table 1), was found to have two de novo microdeletions involving the 1q44ter region and exon 5 of JARID2. The deletion of 1q44 is a recognizable clinical disorder characterized by short stature, DD, ID, microcephaly, facial dysmorphism, variable types of seizure, and partial to complete agenesis of the corpus callosum (ACC) [17-19].