Our group reported somatic missense mutations in PIM1 and cMyc in 46% and 30% of MALT lymphomas (gastric and extragastric origin) and in 30% and 41% of transformed MALT lymphomas and 72% of primary cutaneous marginal zone B cell lymphomas (PCMZL) [52], considered as integral part of MALT lymphomas [53, 54]. The gene discussed is PIM1; the disease is MALT lymphoma.