2002), had the highest concentration in blood after the LPS challenge suggesting extrahepatic synthesis due to inflammation (Ceciliani et al. 2002). Conner et al. (1986) reported higher concentrations of ceruloplasmin in cows with mastitis in comparison with healthy cows. In a previous study (Trevisi et al. 2012), cows with elevated concentrations of ceruloplasmin before parturition but without an increase in plasma haptoglobin, had the worse health conditions during early lactation. This evidence concerns the gene HP and mastitis.