NOTCH4 and arteriosclerosis: 2003). Notch4 has also been shown to be suppressed in allografted vessels during the development of transplant arteriosclerosis, as Notch4 is necessary for endothelial quiescence, survival, and repair in response to tissue injury (Quillard et al. 2008). Also Notch4 has been implicated in pregnancy-induced hypertension (Sahin et al. 2011).