RUNX1 has an osteogenic role in the pathology of osteoarthritis, which was downregulated by a thienoindazole molecule (TD-198946) recently described by Yano et al.30RUNX1 may also have a role in atherosclerotic plaque formation.31 It is intriguing to speculate that RUNX1 may have a similar role in the gallstone matrix in GBD. This evidence concerns the gene RUNX1 and gallstones.