IL6R and coronary artery disorder: Each known genetic perturbation represents an experiment of nature showing the likely directional outcome of an equivalent environmental or pharmacological intervention, similar to the causal role reported for IL6R in relation to coronary heart disease.33 It is evident from the above that enhancing cholesterol breakdown, reducing synthesis and reducing reuptake from plasma should reduce GBD risk, although the third strategy would not be attractive from a vascular perspective.