While both B lymphoid and myeloid leukemia cells harbor PU.1 and TRIM33 at the Bim –117 region, it is important to note that knockdown of TRIM33 in AML does not result in apoptosis or Bim upregulation (Figure 1D and Figure 4—figure supplement 2). This evidence concerns the gene BCL2L11 and acute myeloid leukemia.