Notably, the co-expression of p96ABL/BCR and p185ABL/BCR induced a lymphoid-like leukemia phenotype in 37% of the mice, with the majority of BM cells expressing the B220, and only few myeloid cells and associated with moderate splenomegaly (90–300mg spleen weight)(Fig 6B–6D). The gene discussed is PTPRC; the disease is leukemia.