APOE and Niemann-Pick disease: Although the significance of reduced abundance of ApoE charge forms in the California sea lion is unknown, a reduction in glycoforms of ApoE has been correlated with increased amyloid beta peptide 42 accumulation in a mouse model of Niemann-Pick Disease where a “simplification” of ApoE glycosylation appears to correspond with neurodegeneration via impaired cholesterol trafficking [35].