Consistent with the inhibitory effect of α2,6 sialylation on apoptosis through galectins, Fas and TNFR1, upregulation of ST6Gal I was reported to confer radiation resistance in colon cancer cell lines, as well as multidrug resistance in human acute myeloid leukemia [96,97]. The gene discussed is ST6GAL1; the disease is acute myeloid leukemia.