49 described the effect of HIF-1a expression on clinical outcome and found that HIF-1a expression above 5% results in better survival in OSCC patients. The study of Dos Santos et al. describes a small subgroup of 30 patients treated with surgery and postoperative radiotherapy within a study of 66 OSCC patients 39. The study of Winter et al. 54 describe significantly worse outcome for HNSCC patients with high HIF-1a expression. All other studies did not show a difference in outcome when patients were stratified according to EMH expression. Results are summarized in Table5. Here, HIF1A is linked to head and neck squamous cell carcinoma.