In addition, there are several syndromic OCA genes which associated with Hermansky-Pudlak syndrome (HPS 1–7)[10], Chediak-Higashi syndrome(LYST) [11], and Griscelli syndrome types 1 (MYO5A)[12] and 2 (RAB27A) [13]. This evidence concerns the gene RAB27A and Hermansky-Pudlak syndrome.